Mental disorders represent a significant public health burden worldwide due to their high prevalence, chronically disabling nature, and substantial impact on quality of life.
Despite growing knowledge of the pathological mechanisms that underlie the development of these disorders, a high percentage of patients do not respond to first-line clinical treatments; thus, there is a strong need for alternative therapeutic approaches.
During the past half-century, after the identification of the endocannabinoid system and its role in multiple physiological processes, both natural and synthetic cannabinoids have attracted considerable interest as putative medications in pathological conditions such as, but not exclusive to, mental disorders.
Here, we provide a summary of cannabinoid effects in support of possible therapeutic applications for major depression, bipolar disorder, anxiety, posttraumatic stress disorder, and schizophrenia. Considering this evidence, highlighted benefits and risks of cannabinoid use in the management of these illnesses require further experimental study.
Impact of Mitophagy and Mitochondrial Unfolded Protein Response as New Adaptive Mechanisms Underlying Old Pathologies: Sarcopenia and Non-Alcoholic Fatty Liver Disease
Mitochondria are the first-line defense of the cell in the presence of stressing processes that can induce mitochondrial dysfunction. Under these conditions, the activation of two axes is accomplished, namely, (i) the mitochondrial unfolded protein response (UPRmt) to promote cell recovery and survival of the mitochondrial network; (ii) the mitophagy process to eliminate altered or dysfunctional mitochondria.
For these purposes, the former response induces the expression of chaperones, proteases, antioxidant components and protein import and assembly factors, whereas the latter is signaled through the activation of the PINK1/Parkin and BNIP3/NIX pathways.
These adaptive mechanisms may be compromised during aging, leading to the development of several pathologies including sarcopenia, defined as the loss of skeletal muscle mass and performance; and non-alcoholic fatty liver disease (NAFLD). These age-associated diseases are characterized by the progressive loss of organ function due to the accumulation of reactive oxygen species (ROS)-induced damage to biomolecules, since the ability to counteract the continuous and large generation of ROS becomes increasingly inefficient with aging, resulting in mitochondrial dysfunction as a central pathogenic mechanism.
Nevertheless, the role of the integrated stress response (ISR) involving UPRmt and mitophagy in the development and progression of these illnesses is still a matter of debate, considering that some studies indicate that the prolonged exposure to low levels of stress may trigger these mechanisms to maintain mitohormesis, whereas others sustain that chronic activation of them could lead to cell death. In this review, we discuss the available research that contributes to unveil the role of the mitochondrial UPR in the development of sarcopenia, in an attempt to describe changes prior to the manifestation of severe symptoms; and in NAFLD, in order to prevent or reverse fat accumulation and its progression by means of suitable protocols to be addressed in future studies.
Display Characteristics and Their Impact on Digital Pathology: A Current Review of Pathologists’ Future “Microscope”
Digital displays (monitors) are an indispensable component of a pathologists’ daily workflow, from writing reports, viewing whole-slide images, or browsing the Internet. Due to a paucity of literature and experience surrounding display use and standardization in pathology, the Food and Drug Administration’s (FDA) has currently restricted FDA-cleared whole-slide imaging systems to a specific model of display for each system, which at this time consists of only medical-grade (MG) displays.
Further, given that a pathologists’ display will essentially become their new surrogate “microscope,” it becomes exceedingly important that all pathologists have a basic understanding of fundamental display properties and their functional consequences. This review seeks to: (a) define and summarize the current and emerging display technology, terminology, features, and regulation as they pertain to pathologists and review the current literature on the impact of different display types (e.g. MG vs. consumer off the shelf vs. professional grade) on pathologists’ diagnostic performance and (b) discuss the impact of the recent digital pathology device componentization and the coronavirus disease 2019 public emergency on the pixel pathway and display use for remote digital pathology.
Display technology has changed dramatically over the past 20 years and continues to change at a rapid rate. There is a paucity of published studies to date that investigate how display type affects pathologist performance, with more research necessary in order to develop standards and minimum specifications for displays in digital pathology.
SARS-CoV-2 Spike S1 RBD Protein, Human Fc-Fusion, Avi-Tag |
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| E80025 | EpiGentek |
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AXYPET STARTER KIT 2 AP-10, AP-100 & AP-1000 WITH ADDITIONAL FREE RACKS OF AXYGEN PIPETTE TIPS |
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| AP-STR-KIT-2 | CORNING | 1/pk | EUR 440.4 |
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Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller |
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Recombinant Transmembrane Protease Serine 2 Protein, Partial |
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| E80016 | EpiGentek |
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AxioCam Erc5s rev 2, w/Accessory Kit |
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| ZV-Erc5sAC-Kit | MiTeGen | 1 KIT | EUR 1611 |
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Description: AxioCam Erc5s rev 2, w/Accessory Kit- connection cable Y-USB 2.0.- HDMI cable to DVI-D- SD card- IR remote control |
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Frit Kit |
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| FRIT-KIT | Next Advance | 1each | EUR 148.8 |
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Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool. |
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Column Packing Kit |
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| PACK-KIT | Next Advance | 1pack | EUR 1242 |
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Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar. |
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ACE2, His-Tag Protein |
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| E80019 | EpiGentek |
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PCR Mycoplasma Detection Kit |
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| M034-Kit | TOKU-E | Kit | EUR 319.2 |
DNA Concentrator Kit |
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| P-1006 | EpiGentek |
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Methylamp DNA Modification Kit |
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| P-1001 | EpiGentek |
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EpiQuik Dnmt1 Assay Kit |
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| P-3011 | EpiGentek |
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EpiQuik Dnmt3A Assay Kit |
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| P-3012 | EpiGentek |
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EpiQuik Dnmt3B Assay Kit |
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| P-3013 | EpiGentek |
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TuMinute PCR Clean-Up Kit |
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| P-1005 | EpiGentek |
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Methylamp Universal Methylated DNA Kit |
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| P-1011 | EpiGentek |
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FitAmp Circulating DNA Quantification Kit |
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| P-1012 | EpiGentek |
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Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit |
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| CAS400A-KIT | SBI | 1 kit (10 rxn) | EUR 1332 |
Pesticide Kit Containing All 10 Multi-Compound Mixes |
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| SPXPR-KIT | Scientific Laboratory Supplies | 1ML | EUR 1923.18 |
Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit |
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| CAS410A-KIT | SBI | 1 kit (10 rxn) | EUR 798 |
Cas9-EGFP Protein and T7 gRNA SmartNuclease Synthesis Kit |
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| CAS420A-KIT | SBI | 1 kit (10 rxn) | EUR 828 |
FitAmp Plasma/Serum DNA Isolation Kit |
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| P-1004 | EpiGentek |
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Methylamp One-Step DNA Modification Kit |
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| P-1010 | EpiGentek |
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CMV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV100PA-KIT | SBI | 1 Kit | EUR 1358.4 |
CMV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV105PA-KIT | SBI | 1 Kit | EUR 1358.4 |
MSCV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV120PA-KIT | SBI | 1 Kit | EUR 1358.4 |
MSCV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV125PA-KIT | SBI | 1 Kit | EUR 1358.4 |
Nori Equine MMP-2 ELISA Kit-2 Plates |
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| GR106478-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine TIM-2 ELISA Kit (2 plates) |
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| GR106516-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Human TIM-2 ELISA Kit-2 Plates |
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| GR111039-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Canine TIM-2 ELISA Kit (2 plates) |
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| GR115041-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human Angiopoietin-2 (ANG-2) ELISA Kit (2 plates) |
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| GR106245-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine MMP-2/TIMP-2 Complex ELISA Kit (2 plates) |
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| GR106502-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
FitAmp General Tissue Section DNA Isolation Kit |
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| P-1003 | EpiGentek |
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FitAmp Paraffin Tissue Section DNA Isolation Kit |
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| P-1009 | EpiGentek |
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Multiplex gRNA Kit + EF1-T7-hspCas9-H1-gRNA linearized SmartNuclease vector |
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| CAS700A-KIT | SBI | 10 rxn | EUR 1358.4 |
Multiplex gRNA Kit + CAG-T7-hspCas9-H1-gRNA linearized SmartNuclease vector |
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| CAS720A-KIT | SBI | 10 rxn | EUR 1358.4 |
Multiplex gRNA Kit + CMV-T7-hspCas9-H1-gRNA linearized SmartNuclease vector |
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| CAS740A-KIT | SBI | 10 rxn | EUR 1358.4 |
T7 gRNA SmartNuclease Synthesis Kit (includes CAS510A-1 & T7 IVT synthesis reagents) |
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| CAS510A-KIT | SBI | 1 Kit | EUR 966 |
EpiQuik DNA Methyltransferase (DNMT) Activity/Inhibition Assay Kit |
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| P-3001 | EpiGentek |
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EpiQuik Histone Methyltransferase Activity/Inhibition Assay Kit (H3K4) |
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| P-3002 | EpiGentek |
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EpiQuik Histone Methyltransferase Activity/Inhibition Assay Kit (H3K9) |
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| P-3003 | EpiGentek |
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Cas9 Nickase: CMV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV200PA-KIT | SBI | 1 Kit | EUR 1358.4 |
Cas9 Nickase: CMV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV205PA-KIT | SBI | 1 Kit | EUR 1358.4 |
Cas9 Nickase: MSCV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV220PA-KIT | SBI | 1 Kit | EUR 1358.4 |
Cas9 Nickase: MSCV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV225PA-KIT | SBI | 1 Kit | EUR 1358.4 |
Nori® Human MMP-2/TIMP-2 Complex ELISA Kit (2 plates) |
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| GR106372-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human b-defensin 2 (BD-2) ELISA Kit- 2 Plates |
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| GR111099-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Dr. P Kit-Solution 2 |
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| K2021010-2 | Biochain | 6 ml | EUR 144 |
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Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. |
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Crystal Harvesting Sampler Kit 2 |
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| MSK-2 | MiTeGen | 1 KIT | EUR 642 |
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Description: Crystal Harvesting Sampler Kit 2contains:120 mounts for crystal harvesting and data collection 20 Dual-Thickness MicroMounts (M2-L18SP-A2) 20 Dual-Thickness MicroLoops LD (M5-L18SP-A2LD ) 20 Dual-Thickness MicroLoops (M5-L18SP-A4) 20 MicroMeshes (M3-L18SP-A1) 20 MicroLoops E (M8-L18SP-VA1) 20 MicroGrippers (M7-L18SP-A1) on 18mm/SPINE rods |
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Small Molecule Starter Kit #2 |
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| SMSK-2 | MiTeGen | 1 KIT | EUR 423 |
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Description: Small Molecule Starter Kit #2Contains:20 B4 bases (GB-B4-20)20 Dual Thickenss MicroMounts Medium Aperture Assortment (M2-L18SP-A2)1 tube Apiezon N Cryogenic vacuum grease (APZN-1)1 pair of Heavy-Duty serated end tweezers (TW-1) |
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Nori® Chicken Netrin-2 ELISA Kit (2 plates) |
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| GR106184-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human Tie-2 ELISA Kit (2 plates) |
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| GR106458-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human TIMP-2 ELISA Kit (2 plates) |
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| GR106460-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human Trappin-2 ELISA Kit (2 plates) |
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| GR106467-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Mouse IL-2 ELISA Kit- 2 Plates |
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| GR117024-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Mouse IGFBP-2 ELISA Kit- 2 Plates |
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| GR117043-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Rabbit IL-2 ELISA Kit- 2 Plates |
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| GR144032-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Monkey IL-2 ELISA Kit- 2 Plates |
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| GR169004-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Donkey IL-2 ELISA Kit- 2 Plates |
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| GR170004-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Porcine MMP-2 ELISA Kit- 2 Plates |
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| GR113006-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Chicken MMP-2 ELISA Kit- 2 Plates |
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| GR114008-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Chicken IGFBP-2 ELISA Kit-2 Plates |
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| GR114026-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Multiplex gRNA Kit + Cas9 Nickase: EF1-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector |
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| CAS750A-KIT | SBI | 10 rxn | EUR 1358.4 |
Multiplex gRNA Kit + Cas9 Nickase: CAG-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector |
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| CAS770A-KIT | SBI | 10 rxn | EUR 1358.4 |
Multiplex gRNA Kit + Cas9 Nickase: CMV-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector |
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| CAS790A-KIT | SBI | 10 rxn | EUR 1358.4 |
Cas9 SmartNuclease Extra Ligation Kit [includes 5x ligation buffer (10 ul) and Fast ligase (2.5ul)] |
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| CAS9LIG-KIT | SBI | 1 Kit | EUR 183.6 |
Claritas PPT Grade Minerals Testing Kit for ICP-MS 1000 ug/mL (1000 ppm) 6 each 30mL |
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| SPXMT-KIT | Scientific Laboratory Supplies | 30ML | EUR 237.12 |
PinPoint-FC 293T Platform Kit for Targeted Gene Insertion (includes PIN320A-1, PIN200A-1, PIN510A-1 & PIN600A-1) |
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| PIN320A-KIT | SBI | 1 Kit | EUR 5929.2 |
Claritas PPT Grade Heavy Metals Testing Kit for ICP-MS 1000 ug/mL (1000 ppm) 6 each 30mL |
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| SPXHM-KIT | Scientific Laboratory Supplies | 30ML | EUR 245.1 |
Nori® Canine (dog) IL-2 ELISA Kit (2 plates) |
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| GR106163-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Porcine (pig) IL-2 ELISA Kit (2 plates) |
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| GR106188-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Guinea Pig IL-2 ELISA Kit- 2 Plates |
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| GR171004-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Porcine b-defensin 2 ELISA Kit- 2 Plates |
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| GR113081-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
PinPoint-FC Murine iPSC Platform Kit for Targeted Gene Insertion (includes PIN340iPS-1, PIN200A-1, PIN510A-1 & PIN600A-1) |
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| PIN340iPS-KIT | SBI | 1 Kit | EUR 5929.2 |
MicroRT Room Temperature Starter Kit #2 |
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| RTSK-2 | MiTeGen | 1 KIT | EUR 790 |
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Description: MicroRT Room Temperature Starter Kit #2Contains:1 MicroRT Tubing Kit (RT-T1)1 MicroRT Aligner (RTA-1)20 reusable goniometer bases (GB-B3S-R-20)40 Dual-Thickness MicroMounts (M2-L18SP-A2 & M2-L18SP-A1)1 Set Dehydration Salts (M-CO-121)5 ml Low Viscosity CryoOil (LVCO-5)1 pair of serrated end tweezers (TW-1) |
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Nori Equine MMP-2/TIMP-4 Complex ELISA Kit (2 plates) |
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| GR106503-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine MMP-2/TIMP-1 Complex ELISA Kit (2 plates) |
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| GR106504-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine MMP-3/TIMP-2 Complex ELISA Kit (2 plates) |
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| GR106506-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Equine NADPH Oxydase 2 (NOX2) ELISA Kit-2 Plates |
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| GR106628-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human NADPH Oxydase 2 (NOX2) ELISA Kit-2 Plates |
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| GR111143-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Recombinant TMPRSS2 Protein, Partial |
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| E80017 | EpiGentek |
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Recombinant Novel Coronavirus Spike Glycoprotein(S), Partial |
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| E80018 | EpiGentek |
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Nori® Human MMP-2/TIMP-4 Complex ELISA Kit (2 plates) |
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| GR106373-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human MMP-2/TIMP-1 Complex ELISA Kit (2 plates) |
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| GR106374-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human MMP-3/TIMP-2 Complex ELISA Kit (2 plates) |
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| GR106376-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Porcine MMP-3/TIMP-2 Complex ELISA Kit (2 plates) |
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| GR113095-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine VEGF ELISA Kit-2 Plates |
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| GR106475-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine HGF ELISA Kit-2 Plates |
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| GR106477-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine A1AT ELISA Kit-2 Plates |
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| GR106490-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine A1PI ELISA Kit-2 Plates |
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| GR106491-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine LDHA ELISA Kit-2 Plates |
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| GR106492-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine CRP ELISA Kit-2 Plates |
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| GR106493-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine Uteroglobin ELISA Kit-2 Plates |
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| GR106495-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine eNOS ELISA Kit-2 Plates |
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| GR106499-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine PCNA ELISA Kit-2 Plates |
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| GR106500-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine HMGB1 ELISA Kit (2 plates) |
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| GR106519-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine IgM ELISA Kit (2 plates) |
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| GR106524-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine IgE ELISA Kit (2 plates) |
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| GR106525-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Equine IgG1 ELISA Kit (2 plates) |
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| GR106526-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Human A1AT ELISA Kit-2 Plates |
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| GR111022-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Human A1PI ELISA Kit-2 Plates |
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| GR111023-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Human LDHA ELISA Kit-2 Plates |
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| GR111024-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Human CRP ELISA Kit-2 Plates |
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| GR111025-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Human ACE ELISA Kit-2 Plates |
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| GR111026-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Human Uteroglobin ELISA Kit-2 Plates |
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| GR111027-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Human eNOS ELISA Kit-2 Plates |
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| GR111031-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Human PCNA ELISA Kit-2 Plates |
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| GR111032-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Human DR3 ELISA Kit-2 Plates |
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| GR111049-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Human HSP27 ELISA Kit-2 Plates |
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| GR111050-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Human TFF1 ELISA Kit-2 Plates |
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| GR111052-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Human GSAP ELISA Kit-2 Plates |
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| GR111053-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Human HSP60 ELISA Kit-2 Plates |
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| GR111055-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Bovine A1AT ELISA Kit-2 Plates |
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| GR112012-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Bovine A1PI ELISA Kit-2 Plates |
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| GR112013-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Bovine LDHA ELISA Kit-2 Plates |
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| GR112014-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Porcine TFF1 ELISA Kit-2 Plates |
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| GR113012-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Porcine GSAP ELISA Kit-2 Plates |
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| GR113013-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Porcine DR3 ELISA Kit-2 Plates |
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| GR113015-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Porcine HSP27 ELISA Kit-2 Plates |
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| GR113016-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Porcine HSP60 ELISA Kit-2 Plates |
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| GR113017-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Porcine IL1R1 ELISA Kit-2 Plates |
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| GR113024-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Porcine IL1R2 ELISA Kit-2 Plates |
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| GR113025-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Porcine Prolactin ELISA Kit (2 plates) |
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| GR113027-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Porcine BANK1 ELISA Kit (2 plates) |
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| GR113029-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Porcine LRRC32 ELISA Kit (2 plates) |
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| GR113031-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Porcine FRAT2 ELISA Kit (2 plates) |
|||
| GR113032-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Porcine C1qTNF3/CORS26 Kit (2 plates) |
|||
| GR113034-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Porcine GULP1 ELISA Kit (2 plates) |
|||
| GR113035-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Porcine PLA2R ELISA Kit (2 plates) |
|||
| GR113038-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Canine A1PI ELISA Kit-2 Plates |
|||
| GR115016-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Canine LDHA ELISA Kit-2 Plates |
|||
| GR115017-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Canine CRP ELISA Kit-2 Plates |
|||
| GR115018-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Canine HMGB1 ELISA Kit (2 plates) |
|||
| GR115044-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori Canine Prolactin ELISA Kit (2 plates) |
|||
| GR115048-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
IL-2 (Human) Colorimetric ELISA Detection Kit |
|||
| 79774-2 | BPS Bioscience | 5 x 96 rxns. | EUR 610 |
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Description: The cytokine protein Interleukin-2 is an important factor for the maintenance of_x000D_ CD4+ regulatory T cells. It plays a critical role in the differentiation of CD4+ T cells into a variety of_x000D_ subsets as well as promotes CD8+ T-cell and NK cell cytotoxicity. The Colorimetric Human IL-2_x000D_ Detection Kit is designed for detecting and quantifying human interleukin-2 in cell culture medium._x000D_ Only a few simple steps on a microtiter plate are required for the assay. First, the_x000D_ capture antibody is coated on a 96-well plate. Next, samples containing IL-2 are incubated on the_x000D_ coated plate followed by detecting the captured IL-2 with the detection antibody. Finally, the plate_x000D_ is treated with streptavidin-HRP followed by addition of a colorimetric HRP substrate to produce_x000D_ color, which can then be measured using a UV/Vis spectrophotometer microplate reader. |
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3CL Protease (SARS-CoV-2) Assay Kit |
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| 79955-2 | BPS Bioscience | 384 rxns. | EUR 1265 |
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Description: The 3CL Protease Assay Kit is designed to measure 3CL Protease activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps. 3CL inhibitor GC376 is also included as an inhibitor control. |
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AAVS1 Safe Harbor Targeting Vector 2.0 - All-Purpose Donor (AAVS1-SA-puro-MCS), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site) |
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| GE620A-KIT | SBI | 1 kit | EUR 2558.4 |
AAVS1 Safe Harbor Targeting Vector 2.0 - GOI Knock-in Donor (AAVS1-SA-puro-EF1-MCS), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site) |
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| GE622A-KIT | SBI | 1 kit | EUR 2558.4 |
AAVS1 Safe Harbor Targeting Vector 2.0 - Reporter Knock-in Donor (AAVS1-SA-puro-MCS-GFP), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site) |
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| GE624A-KIT | SBI | 1 kit | EUR 2558.4 |
2-Methoxyestradiol (2-MeOE2) |
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| 27762-2 | BPS Bioscience | 100 mg | EUR 230 |
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Description: 2-Methoxyestradiol (2-MeOE2), an endogenous metabolite of 17β-estradiol (E2), is an inhibitor of microtubule assembly that inhibits the polymerization of tubulin and interferes with mitotic spindle dynamics leading to the blockage of mitosis of human cancer cells which lack estrogen receptors in metaphase. 2-MeOE2 is also an inhibitor of tumor growth and angiogenesis. Study results have shown that 2-MeOE2 induces mammalian cell transformation and genotoxicity in Syrian hamster embryo (SHE) fibroblasts through concentration-dependent inhibition of cell growth. Moreover, 2-MeOE2 has demonstrated anti-proliferative activity against estrogen-responsive breast cancer cell line MCF-7 and subsequent inhibition of the growth of tumors subcutaneously inoculated in mice. |
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Nori® Equine TLR7 ELISA Kit (2 plates) |
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| GR106087-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human TLR5 ELISA Kit (2 plates) |
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| GR106101-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human TLR3 ELISA Kit (2 plates) |
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| GR106104-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Equine TLR9 ELISA Kit (2 plates) |
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| GR106116-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Equine TLR5 ELISA Kit (2 plates) |
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| GR106119-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human TLR7 ELISA Kit (2 plates) |
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| GR106121-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human TLR9 ELISA Kit (2 plates) |
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| GR106122-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Chicken Caronte ELISA Kit (2 plates) |
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| GR106182-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Chicken TLR9 ELISA Kit (2 plates) |
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| GR106185-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human BMP1 ELISA Kit (2 plates) |
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| GR106189-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human BMP2 ELISA Kit (2 plates) |
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| GR106190-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human BMP3 ELISA Kit (2 plates) |
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| GR106191-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human BMP4 ELISA Kit (2 plates) |
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| GR106192-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human BMP5 ELISA Kit (2 plates) |
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| GR106193-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human BMP6 ELISA Kit (2 plates) |
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| GR106194-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human BMP7 ELISA Kit (2 plates) |
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| GR106195-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human BMP8a ELISA Kit (2 plates) |
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| GR106196-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human AgRP ELISA Kit (2 plates) |
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| GR106241-2 | Genorise Scientific | 2 x 96-well | EUR 553.2 |
Nori® Human ALCAM ELISA Kit (2 plates) |
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| GR106242-2 | Genorise Scientific | 2 x 96-well | EUR 553.2 |
Nori® Human Angiogenin ELISA Kit (2 plates) |
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| GR106243-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human BCAM ELISA Kit (2 plates) |
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| GR106249-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human CD14 ELISA Kit (2 plates) |
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| GR106257-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human CD200 ELISA Kit (2 plates) |
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| GR106258-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human CD97 ELISA Kit (2 plates) |
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| GR106260-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human Chemerin ELISA Kit (2 plates) |
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| GR106262-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human DAN ELISA Kit (2 plates) |
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| GR106266-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Nori® Human DcR3 ELISA Kit (2 plates) |
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| GR106267-2 | Genorise Scientific | 2 x 96-well | EUR 998.4 |
Given the complexity of modern displays, pathologists must become better informed regarding display technology if they wish to have more choice over their future “microscopes.”