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Diagnostic Testing & Technology Report

New Bioimaging System Promises Improved HER2 Testing
April 2008

A novel biomaging system may improve the detection of HER2-positive breast cancer, according to a paper published online in the International Journal of Cancer. Researchers at the National Institute of Standards and Technology (NIST), the National Cancer Institute (NCI), and the scientific research firm SAIC found that a chicken immunoglobulin Y (IgY) antibody created against the HER2 protein could be tagged with tiny, intense light sources known as "quantum dots" to more reliably detect the HER2 biomarker than existing diagnostic tests that use mammalian antibodies tagged with conventional fluorescent dyes. Overall, the improvement in sensitivity to the HER2 biomarker was about 40 percent to 50 percent.

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